#3Dmodel#cellculture#remodelling#cancer. The present work is the 3D culture of colon carcinoma cells (Left 10X vs. Right 20X). 3D models are availed for its importance as cell articulator. Most cell culture work is confined in 2D space inside the flasks where they grow and reach to a confluence once it’s run out of space to grow. Drawback is no in vivo like characteristics are observed and thus results from these cell culture work are not translated in human clinical trials. However, 3D organisation of the cells in 3D cell culture gives more in vivo like experience and mimicks the tissue surrounding in addition to the availability of the third dimension.